Pharmacist - my bad! I was in a hurry to finish the post and mistakenly typed bci-221 instead of cli-221 in the last paragraph (edited after reading your post). I think my meaning was clear, however, as I correctly typed the stock number of the carts in the first paragraph, just as the original poster had in the thread title. Since I am still happily using bci-6 cart printers and reside in the US, I have no knowledge of the most recent cli carts except for what I have learned from posts on this forum. If, in fact, the cli-221 designation is correct as stated in the original poster's thread title, and if it holds a smaller volume of ink than bci-6 or cli-8 carts with which I am familiar, I will restate my opinion that it would be more efficient to refill and use bci-6 carts instead of the cli-221 carts in the printers for which bci-6 carts are specified. In addition, the empty chipped carts are more valuable to either hold onto in the event that an older printer dies and you purchase a newer generation canon printer, or they can be traded or sold. You mentioned that the cli chipped carts offer no advantage as they can be glitchy and provide incorrect information to the printers for which they were designed. You are correct that this change was a giant step backward for the consumer but if did satisfy the aim of canon as it made refilling a bit more daunting for many users, The real answer for this thread is that the cli carts offer no advantage for bci-cart printers. Hope this clarifies the error you pointed out in my last post on this thread.